Insight into How Carbon Nanotubes Cause a Thrombus: Activation of Platelets Through “Store-Operated” Calcium Entry
نویسندگان
چکیده
aCenter for Biologics Evaluation and Research (CBER), Office of Blood Research and Review (OBRR), Food and Drug Administration (FDA), Rockville, Maryland 20852; b1st Faculty of Medicine and c3rd Faculty of Medicine, Charles University, Prague, Czech Republic; dNational Institutes of Health, Clinical Center, Bethesda, Maryland, 02892; and eNational Institute of Standards and Technology, Gaithersburg, Maryland 20899
منابع مشابه
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation.
Platelet activation and aggregation at sites of vascular injury are essential for primary hemostasis, but are also major pathomechanisms underlying myocardial infarction and stroke. Changes in [Ca(2+)](i) are a central step in platelet activation. In nonexcitable cells, receptor-mediated depletion of intracellular Ca(2+) stores triggers Ca(2+) entry through store-operated calcium (SOC) channels...
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Platelet activation and aggregation at sites of vascular injury are essential for primary hemostasis, but are also major pathomechanisms underlying myocardial infarction and stroke. Changes in [Ca2 ]i are a central step in platelet activation. In nonexcitable cells, receptormediated depletion of intracellular Ca2 stores triggers Ca2 entry through storeoperated calcium (SOC) channels. STIM1 has ...
متن کاملSTIM and Orai in hemostasis and thrombosis.
At sites of vascular injury, platelets rapidly adhere to the exposed subendothelial extracellular matrix, become activated and, together with the coagulation system, form a plug that seals the lesion. This process is essential to prevent blood loss, however, under pathological conditions it may lead to vessel occlusion. Agonist-induced elevation of intracellular Ca(2+) levels is essential for p...
متن کاملPartially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice
BACKGROUND Serotonin (5-hydroxytryptamin, 5-HT) is an indolamine platelet agonist, biochemically derived from tryptophan. 5-HT is secreted from the enterochromaffin cells into the gastrointestinal tract and blood. Blood 5-HT has been proposed to regulate hemostasis by acting as a vasoconstrictor and by triggering platelet signaling through 5-HT receptor 2A (5HTR2A). Although platelets do not sy...
متن کاملSystems modeling of Ca(2+) homeostasis and mobilization in platelets mediated by IP3 and store-operated Ca(2+) entry.
Resting platelets maintain a stable level of low cytoplasmic calcium ([Ca(2+)]cyt) and high dense tubular system calcium ([Ca(2+)]dts). During thrombosis, activators cause a transient rise in inositol trisphosphate (IP3) to trigger calcium mobilization from stores and elevation of [Ca(2+)]cyt. Another major source of [Ca(2+)]cyt elevation is store-operated calcium entry (SOCE) through plasmalem...
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تاریخ انتشار 2012